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S.E.M.I.: Side Effects May Include...

PC (Microsoft Windows)

Release Date: January 23, 2026
Genres: Hack and slash/Beat 'em up, Indie, Arcade
Themes: Action, Comedy, Party
Game Type: Main game
Game Modes: Single-player, Multiplayer, Co-operative
Player Perspective: Third person
Alternate Titles: SEMI.exe

Overview

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.